HEALTH LIFESTYLE: Systemic Lupus Erythematosus (SLE)
A disease caused by immune complexes. Immune complexes are produced when an antibody response to a soluble antigen. Since the immune response progresses, greater immune complexes formed leading to the activation of complement, activated components that bind to the complexes. These are then efficiently cleared by binding to receptor 1 (CR1) on erythrocytes, the immune complexes across to the liver and spleen form. Since the complexes are removed from the red cell surface by Kupffer cells and other phagocytes (fig. a) and taken through a variety of complement and Fc receptors on the cells lining the sinusoids of the liver and spleen circulation....
